![]() Interobserver agreement for ccLS was evaluated with the Fleiss κ statistic. The distribution of ccRCC by ccLS was tabulated. ![]() The diagnostic performance for ccRCC was calculated using random-effects logistic regression modeling. After a 1.5-hour training session, two abdominal radiologists per center independently rendered a ccLS for 50 masses. Masses with macroscopic fat were excluded. Materials and Methods This retrospective multicenter cross-sectional study included patients with consecutive solid (≥25% approximate volume enhancement) SRMs undergoing multiparametric MRI between December 2012 and December 2019 at five academic medical centers with histologic confirmation of diagnosis. Purpose To evaluate the performance of and interobserver agreement for ccLS to diagnose ccRCC among solid SRMs. When compared with invasive percutaneous biopsies, the objective of the proposed clear cell likelihood score (ccLS) is to classify ccRCC noninvasively by using multiparametric MRI, but it lacks external validation. ![]() Among SRMs, clear cell renal cell carcinoma (ccRCC) is frequently aggressive. Background Solid small renal masses (SRMs) (≤4 cm) represent benign and malignant tumors.
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